Thrombosis and acute lymphoblastic leukaemia.

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India

Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL...

Secondary acute lymphoblastic leukaemia in a multiple myeloma patient

Secondary acute leukaemia (s-ALL) is a destructive complication in patients who have been previously treated for other cancer. Secondary acute lymphoblastic leukaemia is rarely reported whereas secondary acute myeloid leukaemia is much more common. Chromosomal 11q23 abnormality, frequently detected in therapy-related acute myeloid leukaemia, is the most common cytogenetic alteration in secondar...

Cerebral Infarction in Childhood Acute Lymphoblastic Leukaemia Treated with Low Dose E. coli Asparaginase

Received September 16, 2005 Abstract The occurrence of thrombosis complicating L-asparaginase therapy in childhood acute lymphoblastic leukaemia has been supported by both laboratory and clinical evidences, but the exact pathogenic mechanism and predisposing factors remain elusive. Two children with acute lymphoblastic leukaemia (ALL) treated with chemotherapy developed cerebral infarction duri...

Immunophenotypic Subtyping of Leukemic Cells from Iranian Patients with Acute Lymphoblastic Leukaemia: Association to Disease Outcome

Background: Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification, stratification and prognosis of leukaemia. Objective: To investigate the immunophenotypic subtype profiles of Iranian patients with acute lymphoblastic leukemia (ALL) and its association to disease outcome. Methods: In this study, a total of 60 Iranian patients with ...

Bone Scintigraphy in Acute Lymphoblastic Leukemia

Leukemia is the most common childhood cancer and accounts for 30-40% of all malignancies. A retrospective review  was performed of the hospital records of 9 children, 6 boys and 3 girls, aged  from 2.5 to 15 years with ALL initially referred to Nemazee hospital Nuclear medicine center for whole body bone scanning between 2000 and 2002. Bone marrow pathology established ALL (L1) in two and ALL (...